When manufacturing high-value pharmaceutical products, combating product contamination is critical because of the effect an impure batch can have on the business and most importantly to its users.
One potential source of contamination is from pressure relief valves (PRVs) used to prevent overpressure during the production process.
However, due to their multiple-component structure and operation, PRVs are…
- not always sealed and may allow foreign substances to enter the process.
- often subject to corrosion due to their numerous components and material types.
- difficult if not impossible to clean, especially after venting product.
- prone to “weep” once operating pressures approach the set pressure.
Register for the Fike Pressure Relief Webinar: Combating Product Contamination In Pharma Manufacturing
DATE: Thursday April 28
TIME: 9-10am CDT/4-5pm CEST
PRESENTER: Michael Krebill
Rupture Discs’ Effects on Product Contamination
Fike rupture discs are often used to replace PRVs in these processes not only because of their superior pressure relief performance and lower total cost of ownership, but also because of their advantages in combating product contamination:
LEAK TIGHT, HERMETICALLY SEALED
ELECTRO-POLISHING AND PASSIVATION CAPABILITIES
CIP/SIP PROCESS COMPATIBILITY
3-A HYGENIC/ SANITARY STANDARDS COMPLIANCE
Axius® CAROLINA DEL SUR
Fike’s Axius SC is engineered to achieve a smooth, crevice-free design to help meet 3A compliance and to meet the unique hygienic demands to address the industry’s concern with product contamination. This premium rupture disc is engineered and manufactured with Fike’s patented G2 technology, which offers the highest operating ratios, tightest burst tolerances and greatest life cycles.
Axius SC is manufactured in both the US and EU, which dramatically minimizes lead times for both new installations and for rupture disc replacements minimizing downtime.